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Interferon α-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-1.

Abstract:

BACKGROUND: Natural killer (NK) cells are an important component of the innate immune defense against viruses, including hepatitis C virus (HCV). The cell culture system using HCV-permissive Huh-7.5 cells make studies on interaction of NK cells and HCV-infected target cells possible. We used this system to characterize interactions of HCV-infected Huh-7.5 cells and NK cells from healthy controls and patients with acute HCV infection. METHODS: IFNα- and IL-2 stimulated NK cells were cultured ...

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Publisher copy:
10.1093/infdis/jis210

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Journal:
The Journal of infectious diseases
Volume:
205
Issue:
9
Pages:
1351-1362
Publication date:
2012-05-29
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:be6e1ea8-2d9f-4581-9506-b659e48146ae
Source identifiers:
426217
Local pid:
pubs:426217

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