Control of cyclin C levels during development of Dictyostelium.

Journal article

BACKGROUND: Cdk8 and its partner cyclin C form part of the mediator complex which links the basal transcription machinery to regulatory proteins. The pair are required for correct regulation of a subset of genes and have been implicated in control of development in a number of organisms including the social amoeba Dictyostelium discoideum. When feeding, Dictyostelium amoebae are unicellular but upon starvation they aggregate to form a multicellular structure which develops into a fruiting bo...

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Authors: Greene, D; Hsu, D; Pears, C

• Publication status: Published
• Journal: PloS one
• Volume: 5
• Issue: 5
• Pages: e10543
• Publication date: 2010-01-01
• DOI: 10.1371/journal.pone.0010543
• EISSN: 1932-6203
• ISSN: 1932-6203
• Language: English
• Keywords: Amino Acid Sequence; Animals; Phenotype; Open Reading Frames; Dictyostelium; Oxidative Stress; Chemical Fractionation; Promoter Regions, Genetic; Cyclin C; Molecular Weight; Cyclin-Dependent Kinase 8; Signal Transduction; Intracellular Space; Molecular Sequence Data; Cyclic AMP; Hydrogen Peroxide