Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates.

Journal article

BACKGROUND: Burkholderia thailandensis is a non-pathogenic environmental saprophyte closely related to Burkholderia pseudomallei, the causative agent of the often fatal animal and human disease melioidosis. To study B. thailandensis genomic variation, we profiled 50 isolates using a pan-genome microarray comprising genomic elements from 28 Burkholderia strains and species. RESULTS: Of 39 genomic regions variably present across the B. thailandensis strains, 13 regions corresponded to known ge...

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Authors: Sim, B; Chantratita, N; Ooi, W; Nandi, T; Tewhey, R

• Publication status: Published
• Journal: Genome biology
• Volume: 11
• Issue: 8
• Pages: R89
• Publication date: 2010-01-01
• DOI: 10.1186/gb-2010-11-8-r89
• EISSN: 1465-6914
• ISSN: 1465-6906
• Language: English
• Keywords: Metabolic Networks and Pathways; Multigene Family; Genome, Bacterial; Burkholderia; Humans; Virulence; Burkholderia Infections; Genetic Speciation; Animals; Polysaccharides, Bacterial; Mice; Genetic Variation