Journal article
Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9–10 year-old children
- Abstract:
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Aim To examine whether low circulating vitamin C concentrations and low fruit and vegetable intakes were associated with insulin resistance and other Type 2 diabetes risk markers in childhood.
Methods We conducted a cross-sectional, school-based study in 2025 UK children aged 9–10 years, predominantly of white European, South-Asian and black African origin. A 24-h dietary recall was used to assess fruit, vegetable and vitamin C intakes. Height, weight and fat mass were measured and a fasting blood sample collected to measure plasma vitamin C concentrations and Type 2 diabetes risk markers.
Results In analyses adjusting for confounding variables (including socio-economic status), a one interquartile range higher plasma vitamin C concentration (30.9 μmol/l) was associated with a 9.6% (95% CI 6.5, 12.6%) lower homeostatic model assessment of insulin resistance value, 0.8% (95% CI 0.4, 1.2%) lower fasting glucose, 4.5% (95% CI 3.2, 5.9%) lower urate and 2.2% (95% CI 0.9, 3.4%) higher HDL cholesterol. HbA1c concentration was 0.6% (95% CI 0.2, 1.0%) higher. Dietary fruit, vegetable and total vitamin C intakes were not associated with any Type 2 diabetes risk markers. Lower plasma vitamin C concentrations in South-Asian and black African-Caribbean children could partly explain their higher insulin resistance.
Conclusions Lower plasma vitamin C concentrations are associated with insulin resistance and could partly explain ethnic differences in insulin resistance. Experimental studies are needed to establish whether increasing plasma vitamin C can help prevent Type 2 diabetes at an early stage.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 94.2KB, Terms of use)
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(Supplementary materials, zip, 40.5KB, Terms of use)
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- Publisher copy:
- 10.1111/dme.13006
Authors
- Funder identifier:
- https://ror.org/050rgn017
- Grant:
- BDA 11/0004317
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 068362/Z/02/Z
- Publisher:
- Wiley
- Journal:
- Diabetic Medicine More from this journal
- Volume:
- 33
- Issue:
- 3
- Pages:
- 307–315
- Publication date:
- 2015-11-23
- Acceptance date:
- 2015-10-19
- DOI:
- EISSN:
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1464-5491
- ISSN:
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0742-3071
- Language:
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English
- Pubs id:
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pubs:612207
- UUID:
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uuid:be63f051-1632-4edc-9614-a99e16427b1c
- Local pid:
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pubs:612207
- Source identifiers:
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612207
- Deposit date:
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2016-03-30
Terms of use
- Copyright holder:
- Donin et al
- Copyright date:
- 2015
- Rights statement:
- © 2015 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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