- Abstract:
-
The neural cell adhesion molecule (NCAM) is required for cell type segregation during pancreatic islet organogenesis. We have investigated the functional consequences of ablating NCAM on pancreatic beta-cell function. In vivo, NCAM(-/-) mice exhibit impaired glucose tolerance and basal hyperinsulinemia. Insulin secretion from isolated NCAM(-/-) islets is enhanced at glucose concentrations below 15 mM but inhibited at higher concentrations. Glucagon secretion from pancreatic alpha-cells evoked...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1210/en.2008-0475
-
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- Journal:
- Endocrinology
- Volume:
- 150
- Issue:
- 7
- Pages:
- 3067-3075
- Publication date:
- 2009-07-05
- DOI:
- EISSN:
-
1945-7170
- ISSN:
-
0013-7227
- URN:
-
uuid:be5f5c31-44c7-49c5-a2f9-13dbe37608b0
- Source identifiers:
-
18151
- Local pid:
- pubs:18151
- Copyright date:
- 2009
Journal article
Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.
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