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Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.

Abstract:

The neural cell adhesion molecule (NCAM) is required for cell type segregation during pancreatic islet organogenesis. We have investigated the functional consequences of ablating NCAM on pancreatic beta-cell function. In vivo, NCAM(-/-) mice exhibit impaired glucose tolerance and basal hyperinsulinemia. Insulin secretion from isolated NCAM(-/-) islets is enhanced at glucose concentrations below 15 mM but inhibited at higher concentrations. Glucagon secretion from pancreatic alpha-cells evoked...

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Publication status:
Published

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Publisher copy:
10.1210/en.2008-0475

Authors


Olofsson, CS More by this author
Håkansson, J More by this author
Bengtsson, M More by this author
Galvanovskis, J More by this author
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Journal:
Endocrinology
Volume:
150
Issue:
7
Pages:
3067-3075
Publication date:
2009-07-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:be5f5c31-44c7-49c5-a2f9-13dbe37608b0
Source identifiers:
18151
Local pid:
pubs:18151

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