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Therapeutic targeting of FOXP3-positive regulatory T cells using a FOXP3 peptide vaccine WO2008081581.

Abstract:

BACKGROUND: CD4(+)CD25(+) regulatory T cells (Tregs) regulate immunotolerance. Treg depletion causes autoimmune disease, whereas Treg expansion can prevent effective immunosurveillance of 'non-self' antigens in many clinical settings, including cancer. OBJECTIVE: Patent WO2008081581 presents an invention to target Tregs therapeutically via vaccination with immunogenic peptides from the forkhead box P3 (FOXP3) transcription factor. Our objective was the scientific evaluation of this patent an...

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Publisher copy:
10.1517/13543770902785183

Authors


Journal:
Expert opinion on therapeutic patents
Volume:
19
Issue:
7
Pages:
1023-1028
Publication date:
2009-07-01
DOI:
EISSN:
1744-7674
ISSN:
1354-3776
Source identifiers:
246567
Language:
English
Keywords:
Pubs id:
pubs:246567
UUID:
uuid:be5da4a2-885b-413f-bedd-73ed1ba3cb01
Local pid:
pubs:246567
Deposit date:
2012-12-19

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