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In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.

Abstract:

OBJECTIVE: To detect and determine disease severity of osteoarthritis (OA) using a probe activated by matrix metalloproteinase-13 (MMP-13) in vivo in the murine destabilised medial meniscus (DMM) surgical model of OA. DESIGN: We have previously described MMP12ap and MMP13ap, internally quenched fluorescent peptide substrate probes that are activated respectively by MMP-12 and MMP-13. Here we used these probes to follow enzyme activity in vivo in mice knees 4, 6 and 8 weeks following DMM surge...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.joca.2014.04.006

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Meinjohanns, E More by this author
Bou-Gharios, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
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Grant:
Arthritis Research UK Centre for OA Pathogenesis
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Grant:
FP6 CAMP and FP7 LIVIMODE
Publisher:
Elsevier Publisher's website
Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Journal website
Volume:
22
Issue:
6
Pages:
862-868
Publication date:
2014-06-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:be57902b-57e5-43e5-a93b-8d2a1db77162
Source identifiers:
463208
Local pid:
pubs:463208

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