Journal article icon

Journal article

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.

Abstract:

OBJECTIVE: To detect and determine disease severity of osteoarthritis (OA) using a probe activated by matrix metalloproteinase-13 (MMP-13) in vivo in the murine destabilised medial meniscus (DMM) surgical model of OA. DESIGN: We have previously described MMP12ap and MMP13ap, internally quenched fluorescent peptide substrate probes that are activated respectively by MMP-12 and MMP-13. Here we used these probes to follow enzyme activity in vivo in mice knees 4, 6 and 8 weeks following DMM surge...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.joca.2014.04.006

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More from this funder
Grant:
Arthritis Research UK Centre for OA Pathogenesis
More from this funder
Grant:
FP6CAMP
FP7LIVIMODE
Publisher:
Elsevier Publisher's website
Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Journal website
Volume:
22
Issue:
6
Pages:
862-868
Publication date:
2014-06-01
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
Source identifiers:
463208

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP