- Abstract:
-
OBJECTIVE: To detect and determine disease severity of osteoarthritis (OA) using a probe activated by matrix metalloproteinase-13 (MMP-13) in vivo in the murine destabilised medial meniscus (DMM) surgical model of OA. DESIGN: We have previously described MMP12ap and MMP13ap, internally quenched fluorescent peptide substrate probes that are activated respectively by MMP-12 and MMP-13. Here we used these probes to follow enzyme activity in vivo in mice knees 4, 6 and 8 weeks following DMM surge...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 2.8mb)
-
- Publisher copy:
- 10.1016/j.joca.2014.04.006
-
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- Grant:
- Arthritis Research UK Centre for OA Pathogenesis
- Publisher:
- Elsevier Publisher's website
- Journal:
- Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Journal website
- Volume:
- 22
- Issue:
- 6
- Pages:
- 862-868
- Publication date:
- 2014-06-05
- DOI:
- EISSN:
-
1522-9653
- ISSN:
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1063-4584
- URN:
-
uuid:be57902b-57e5-43e5-a93b-8d2a1db77162
- Source identifiers:
-
463208
- Local pid:
- pubs:463208
- Language:
- English
- Keywords:
- Copyright holder:
- Osteoarthritis Research Society International
- Copyright date:
- 2014
- Notes:
- Copyright © 2014 Osteoarthritis Research Society International. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Journal article
In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.
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