Journal article icon

Journal article

Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes.

Abstract:

Modulation of Ca(2+) homoeostasis in cardiac myocytes plays a major role in beat-to-beat regulation of heart function. Previous studies suggest that sphingosine-1-phosphate (S1P), a biologically active sphingomyelin metabolite, regulates Ca(2+) handling in cardiac myocytes, but the underlying mechanism is unclear. In the present study, we tested the hypothesis that S1P-induced functional alteration of intracellular Ca(2+) handling includes the L-type calcium channel current (ICa,L) via a sign...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1007/s11010-016-2752-8

Authors


More by this author
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
Expand authors...
More from this funder
Grant:
PG11/59/29006, PG/12/21/29473
Publisher:
Springer Verlag Publisher's website
Journal:
Molecular and Cellular Biochemistry Journal website
Volume:
419
Issue:
1
Pages:
83-92
Publication date:
2016-07-02
Acceptance date:
2016-06-21
DOI:
EISSN:
1573-4919
ISSN:
0300-8177
Pubs id:
pubs:634205
URN:
uri:be505d10-f188-4a8b-ae79-705f03d16722
UUID:
uuid:be505d10-f188-4a8b-ae79-705f03d16722
Local pid:
pubs:634205
Paper number:
1

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP