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Location of a constriction in the lumen of a transmembrane pore by targeted covalent attachment of polymer molecules.

Abstract:

Few methods exist for obtaining the internal dimensions of transmembrane pores for which 3-D structures are lacking or for showing that structures determined by crystallography reflect the internal dimensions of pores in lipid bilayers. Several approaches, involving polymer penetration and transport, have revealed limiting diameters for various pores. But, in general, these approaches do not indicate the locations of constrictions in the channel lumen. Here, we combine cysteine mutagenesis an...

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Publication status:
Published

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Publisher copy:
10.1085/jgp.117.3.239

Authors


Movileanu, L More by this author
Howorka, S More by this author
Journal:
The Journal of general physiology
Volume:
117
Issue:
3
Pages:
239-252
Publication date:
2001-03-05
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:be385058-c724-4723-a24b-a256c1a77d34
Source identifiers:
52342
Local pid:
pubs:52342

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