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Journal article

Anti-lymphocyte function associated antigen-1 inhibits T-helper 2 function of human allergen-specific CD4+ T cells.

Abstract:

BACKGROUND: Blockade of lymphocyte function associated antigen-1 (LFA-1) is proving successful in the management of psoriasis and other inflammatory skin conditions including atopic dermatitis (AD), but the dependence of allergen-specific CD4+ T-cell function on LFA-1 has not been studied extensively. OBJECTIVES: We sought to investigate the potential ability of LFA-1 inhibition to influence keratinocyte presentation of allergen to specific T-helper (Th) 2 cell clones. METHODS: Using human le...

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Publication status:
Published

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Journal:
The British journal of dermatology
Volume:
158
Issue:
3
Pages:
456-462
Publication date:
2008-03-05
DOI:
EISSN:
1365-2133
ISSN:
0007-0963
URN:
uuid:be2f1c6e-4182-488a-b0c3-947e678a822e
Source identifiers:
6834
Local pid:
pubs:6834

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