Journal article icon

Journal article

Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.

Abstract:

IL-10 is an anti-inflammatory cytokine produced in the joint in rheumatoid arthritis by macrophages and infiltrating blood lymphocytes. Regulation of its expression is poorly understood, but previous findings have suggested that physical interactions with T cells may play a role. This report investigates signalling mechanisms involved in the production of macrophage IL-10 upon interaction with fixed, cytokine-stimulated T cells (Tck). Elutriated monocytes were differentiated to macrophages by...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1186/ar385

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Arthritis research
Volume:
4
Issue:
1
Pages:
64-70
Publication date:
2002-01-01
DOI:
EISSN:
1465-9913
ISSN:
1465-9905
URN:
uuid:be23b904-bba6-4b13-baf2-fafc0bbd2238
Source identifiers:
224146
Local pid:
pubs:224146

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP