Journal article
Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.
- Abstract:
-
IL-10 is an anti-inflammatory cytokine produced in the joint in rheumatoid arthritis by macrophages and infiltrating blood lymphocytes. Regulation of its expression is poorly understood, but previous findings have suggested that physical interactions with T cells may play a role. This report investigates signalling mechanisms involved in the production of macrophage IL-10 upon interaction with fixed, cytokine-stimulated T cells (Tck). Elutriated monocytes were differentiated to macrophages by...
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- Publication status:
- Published
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- Publisher copy:
- 10.1186/ar385
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Bibliographic Details
- Journal:
- Arthritis research
- Volume:
- 4
- Issue:
- 1
- Pages:
- 64-70
- Publication date:
- 2002-01-01
- DOI:
- EISSN:
-
1465-9913
- ISSN:
-
1465-9905
- URN:
-
uuid:be23b904-bba6-4b13-baf2-fafc0bbd2238
- Source identifiers:
-
224146
- Local pid:
- pubs:224146
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2002
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