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Journal article

The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos.

Abstract:

MMP activities are controlled by a combination of proteolytic pro-enzyme activation steps and inhibition by endogenous inhibitors like alpha2-macroglobulin and the tissue inhibitors of metalloproteinases (TIMPs). TIMPs are the key inhibitors in tissue. The expression of both MMPs and TIMPs is controlled during tissue remodeling to maintain a balance in the turnover of extracellular matrix. Disruption of this balance may result in a broad spectrum of diseases. Additionally, TIMP-2 has been rep...

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Publication status:
Published

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Publisher copy:
10.1007/s00427-003-0333-9

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Sarras, MP More by this author
Journal:
Development genes and evolution
Volume:
213
Issue:
8
Pages:
382-389
Publication date:
2003-08-05
DOI:
EISSN:
1432-041X
ISSN:
0949-944X
URN:
uuid:be0fb91c-8f74-4890-8cd8-5f1a44a8481a
Source identifiers:
226994
Local pid:
pubs:226994

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