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IDO induces expression of a novel tryptophan transporter in mouse and human tumor cells

Abstract:

IDO is the rate-limiting enzyme in the kynurenine pathway, catabolizing tryptophan to kynurenine. Tryptophan depletion by IDO-expressing tumors is a common mechanism of immune evasion inducing regulatory T cells and inhibiting effector T cells. Because mammalian cells cannot synthesize tryptophan, it remains unclear how IDO+ tumor cells overcome the detrimental effects of local tryptophan depletion.We demonstrate that IDO+ tumor cells express a novel amino acid transporter, which accounts for...

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Publisher copy:
10.4049/jimmunol.1000815

Authors


Vallius, L More by this author
Karydis, I More by this author
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Journal:
Journal of Immunology
Volume:
187
Issue:
4
Pages:
1617-1625
Publication date:
2011-08-15
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:be093925-417b-4bd6-a385-1bc40c1518c0
Source identifiers:
179500
Local pid:
pubs:179500
Language:
English

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