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Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells.

Abstract:

In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emerge...

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Authors


Böiers, C More by this author
Carrelha, J More by this author
Lutteropp, M More by this author
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Journal:
Cell stem cell
Volume:
13
Issue:
5
Pages:
535-548
Publication date:
2013-11-07
EISSN:
1875-9777
URN:
uuid:be04ea65-1452-446d-a2e2-b88c3941545b
Source identifiers:
474892
Local pid:
pubs:474892
Language:
English

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