Carbonyl reduction of an anti-insect agent imidazole analogue of metyrapone in soil bacteria, invertebrate and vertebrate species.

Journal article

Carbonyl reduction to the respective alcohol metabolites of the anti-insect agent imidazole analogue of metyrapone, NKI 42255 (2-(1-imidazolyl)-1-(4-methoxyphenyl)-2-methyl-1-propanone) and its parent compound metyrapone was characterized in subcellular fractions previously described bacterial and mammalian hydroxysteroid dehydrogenases/carbonyl from soil bacteria, as well as insect, invertebrate and teleost species. The enzymes involved in this metabolic step were characterized with respect ...

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Authors: Oppermann, U; Nagel, G; Belai, I; Bueld, J; Genti-Raimondi, S

• Journal: Chemico-biological interactions
• Volume: 114
• Issue: 3
• Pages: 211-224
• Publication date: 1998-07-01
• DOI: 10.1016/s0009-2797(98)00057-x
• EISSN: 1872-7786
• ISSN: 0009-2797
• Language: English
• Keywords: Insecticides; Bacteria; Electrophoresis, Polyacrylamide Gel; Subcellular Fractions; Soil Microbiology; Hydroxysteroid Dehydrogenases; Blotting, Western; Vertebrates; Biodegradation, Environmental; Oxidation-Reduction; Alcohol Oxidoreductases; Antibody Specificity; Cross Reactions; Invertebrates; Animals; Metyrapone