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The search for the MEN1 gene. The European Consortium on MEN-1.

Abstract:

The search for the gene whose mutations predispose individuals to multiple endocrine neoplasia type 1 (MEN-1) started in 1988 when the MEN1 locus was assigned to 11q13, close to PYGM. It came to an end with the recent identification of a gene expressed ubiquitously which harbours inactivating mutations associated with MEN-1. During these nine years, the genetic linkage interval had been slowly reduced, and losses of heterozygosity (LOH) in MEN-1 tumours had given strong indications that MEN1 ...

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Publication status:
Published

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Authors


Van de Ven, WJM More by this author
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Volume:
243
Issue:
6
Pages:
441-446
Publication date:
1998-06-05
DOI:
EISSN:
1365-2796
ISSN:
0954-6820
URN:
uuid:bdeec337-1bb1-4952-9679-b554ae7cfacf
Source identifiers:
22961
Local pid:
pubs:22961

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