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Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma

Abstract:

Oncogenic ubiquitin-specific protease 22 (USP22) is implicated in a variety of tumours; however, evidence of its role and underlying molecular mechanisms in cholangiocarcinoma (CCA) development remains unknown. We collected paired tumour and adjacent non-tumour tissues from 57 intrahepatic CCA (iCCA) patients and evaluated levels of the USP22 gene and protein by qPCR and immunohistochemistry. Both the mRNA and protein were significantly upregulated, correlated with the malignant invasion and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41419-021-03940-0

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Role:
Author
ORCID:
0000-0002-2796-2598
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Role:
Author
ORCID:
0000-0002-1332-0164
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Name:
National Natural Science Foundation of China
Publisher:
Springer Nature
Journal:
Cell Death and Disease More from this journal
Volume:
12
Issue:
7
Article number:
678
Publication date:
2021-07-05
Acceptance date:
2021-06-15
DOI:
EISSN:
2041-4889
Pmid:
34226501
Language:
English
Keywords:
Pubs id:
1185517
Local pid:
pubs:1185517
Deposit date:
2022-11-11

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