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Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females.

Abstract:

Throughout every pregnancy, genetically distinct fetal microchimeric stem/progenitor cells (FMCs) engraft in the mother, persist long after delivery, and may home to damaged maternal tissues. Phenotypically normal fetal lymphoid progenitors have been described to develop in immunodeficient mothers in a fetus-treats-its-mother paradigm. Since stem cells contribute to muscle repair, we assessed this paradigm in the mdx mouse model of Duchenne muscular dystrophy. mdx females were bred serially t...

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Publication status:
Published

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Publisher copy:
10.1089/scd.2012.0047

Authors


Seppanen, EJ More by this author
Hodgson, SS More by this author
Khosrotehrani, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Stem cells and development
Volume:
21
Issue:
15
Pages:
2809-2816
Publication date:
2012-10-05
DOI:
EISSN:
1557-8534
ISSN:
1547-3287
URN:
uuid:bdeca4a8-00ae-492a-8aef-931bb87d89f2
Source identifiers:
341190
Local pid:
pubs:341190

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