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Structure and dynamics of the membrane-bound cytochrome P450 2C9

Abstract:

The microsomal, membrane-bound, human cytochrome P450 (CYP) 2C9 is a liver-specific monooxygenase essential for drug metabolism. CYPs require electron transfer from the membrane-bound CYP reductase (CPR) for catalysis. The structural details and functional relevance of the CYP-membrane interaction are not understood. From multiple coarse grained molecular simulations started with arbitrary configurations of protein-membrane complexes, we found two predominant orientations of CYP2C9 in the mem...

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Authors


Cojocaru, V More by this author
Balali-Mood, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
PLoS Computational Biology
Volume:
7
Issue:
8
Publication date:
2011-08-05
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
URN:
uuid:bde695de-be05-4955-a640-ae00515e797b
Source identifiers:
179683
Local pid:
pubs:179683
Language:
English

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