- Abstract:
-
Two compounds have recently been described which act as potent benzodiazepine (BDZ) antagonists in vivo and which, in vitro, show high affinity and selectivity for the BDZ receptor of the mammalian central nervous system (CNS). One, ethyl β-carboline-3-carboxylate (β-CCE), was extracted from human urine and may be related to an endogenous ligand for the BDZ, receptor. It reverses the effects of BDZs in vivo and in vitro, but also has intrinsic activity, as it loweres the seizure threshold to ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/295436a0
-
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- Journal:
- Nature
- Volume:
- 295
- Issue:
- 5848
- Pages:
- 436-438
- Publication date:
- 1982-02-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:bde47eca-0018-4d75-9168-91e5e355bcb9
- Source identifiers:
-
185968
- Local pid:
- pubs:185968
- Copyright date:
- 1982
Journal article
Unusual interactions of benzodiazepine receptor antagonists.
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