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Unusual interactions of benzodiazepine receptor antagonists.

Abstract:

Two compounds have recently been described which act as potent benzodiazepine (BDZ) antagonists in vivo and which, in vitro, show high affinity and selectivity for the BDZ receptor of the mammalian central nervous system (CNS). One, ethyl β-carboline-3-carboxylate (β-CCE), was extracted from human urine and may be related to an endogenous ligand for the BDZ, receptor. It reverses the effects of BDZs in vivo and in vitro, but also has intrinsic activity, as it loweres the seizure threshold to ...

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Publication status:
Published

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Publisher copy:
10.1038/295436a0

Authors


Little, HJ More by this author
Journal:
Nature
Volume:
295
Issue:
5848
Pages:
436-438
Publication date:
1982-02-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:bde47eca-0018-4d75-9168-91e5e355bcb9
Source identifiers:
185968
Local pid:
pubs:185968

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