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Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.

Abstract:

Progressive multifocal leukoencephalopathy (PML), caused by replication of JC virus in oligodendrocytes of immunocompromised patients, is diagnosed by polymerase chain reaction-based demonstration of JC virus DNA. We investigated whether MRI might be used to assess disease activity. Diffusion-weighted imaging (DWI) was obtained in two patients with PML, in whom it was the only MRI sequence on which we could identify areas of progressive disease. The extent of abnormal diffusion appeared to co...

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Publisher copy:
10.1007/s00234-003-0966-4

Authors


Herrlinger, U More by this author
Schmidt, F More by this author
Journal:
Neuroradiology
Volume:
45
Issue:
10
Pages:
717-721
Publication date:
2003-10-05
DOI:
EISSN:
1432-1920
ISSN:
0028-3940
URN:
uuid:bddf70b4-017e-4214-a39e-f173afbce7b6
Source identifiers:
242111
Local pid:
pubs:242111

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