Journal article icon

Journal article

The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.

Abstract:

Human immunodeficiency virus type 1 (HIV-1) mutates to escape immune selection pressure, but there is little evidence of selection mediated through HLA-A2, the dominant class I allele in persons infected with clade B virus. Moreover, HLA-A2-restricted responses are largely absent in the acute phase of infection as the viral load is being reduced, suggesting that circulating viruses may lack immunodominant epitopes targeted through HLA-A2. Here we demonstrate an A2-restricted epitope within Vp...

Expand abstract

Actions


Access Document


Authors


Altfeld, M More by this author
Kalife, ET More by this author
Expand authors...
Journal:
Journal of virology
Volume:
79
Issue:
8
Pages:
5000-5005
Publication date:
2005-04-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:bdd1c4a0-528a-4bb1-a8c3-0d99672c54aa
Source identifiers:
191110
Local pid:
pubs:191110

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP