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Human iPSC-derived mesoangioblasts, like their tissue-derived counterparts, suppress t cell proliferation through IDO- and PGE-2-dependent pathways [v1; ref status: Approved 1, http://f1000r.es/x3]

Abstract:

Human mesoangioblasts are currently in a phase I/II clinical trial for the treatment of patients with Duchenne muscular dystrophy. However, limitations associated with the finite life span of these cells combined with the significant numbers of mesoangioblasts required to treat all of the skeletal muscles in these patients restricts their therapeutic potential. Induced pluripotent stem cell (iPSC)-derived mesoangioblasts may provide the solution to this problem. Although, the idea of using iP...

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Journal:
F1000 Research
Volume:
2
Issue:
1
Pages:
1-12
Publication date:
2013-01-01
DOI:
EISSN:
1759-796X
URN:
uuid:bdce8684-644b-49e1-bd61-8b4540c2faf9
Source identifiers:
432533
Local pid:
pubs:432533

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