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Neural representation of reward in recovered depressed patients.

Abstract:

INTRODUCTION: Anhedonia, a loss of interest and pleasure in normally rewarding stimuli, is a key diagnostic criterion for major depression. It has been suggested that deficits in the processing of reward-relevant stimuli could represent an endophenotype for depression. We hypothesized that people at risk of depression by virtue of a personal history of the illness would show impaired neural responses to a primary rewarding stimulus. MATERIALS AND METHODS: Using functional magnetic resonance i...

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Publication status:
Published

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Publisher copy:
10.1007/s00213-009-1573-9

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Psychopharmacology
Volume:
205
Issue:
4
Pages:
667-677
Publication date:
2009-09-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:bdc0ace0-b230-489c-93aa-2df7bcc2b441
Source identifiers:
139466
Local pid:
pubs:139466

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