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Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.

Abstract:

Overproduction of nitric oxide (NO) by inducible NO synthase contributes toward refractory hypotension, impaired microvascular perfusion, and end-organ damage in septic shock patients. Tetrahydrobiopterin (BH4) is an essential NOS cofactor. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme for BH4 biosynthesis. Under inflammatory conditions, GCH1 activity and hence BH4 levels are increased, supporting pathological NOS activity. GCH1 activity can be controlled through allosteric interact...

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Publication status:
Published

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Journal:
Shock (Augusta, Ga.)
Volume:
42
Issue:
5
Pages:
432-439
Publication date:
2014-11-05
DOI:
EISSN:
1540-0514
ISSN:
1073-2322
URN:
uuid:bdbf9acf-a88b-45df-a201-35b0c835f584
Source identifiers:
477586
Local pid:
pubs:477586

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