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Human artificial chromosomes containing chromosome 17 alphoid DNA maintain an active centromere in murine cells but are not stable.

Abstract:

Human artificial chromosomes (HACs) are autonomous molecules that can function and segregate as normal chromosomes in human cells. De novo HACs have successfully been used as gene expression vectors to complement genetic deficiencies in human cultured cells. HACs now offer the possibility of studying the regulation and expression of large genes in a variety of cell types from different tissues and correcting gene deficiencies caused by human inherited diseases. Complementary gene expression s...

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Publication status:
Published

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Publisher copy:
10.1016/j.ygeno.2003.11.011

Authors


Alazami, AM More by this author
Mejía, JE More by this author
Monaco, ZL More by this author
Journal:
Genomics
Volume:
83
Issue:
5
Pages:
844-851
Publication date:
2004-05-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:bdba7552-2e10-4ee0-9156-6efba43b94f8
Source identifiers:
53474
Local pid:
pubs:53474

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