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Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia.

Abstract:

The chromosomal abnormality represented by an isodicentric X chromosome [idic(X)(q13)] is associated with a subset of acute myeloid leukemia (AML) and preleukemia observed in elderly females. A previous study localized the breakpoints of two acquired isodicentric X chromosomes associated with myelodysplasia to a 450-kb region proximal to the XIST gene. Here we report the construction and extensive characterization of a reliable 1-Mb P1 artificial chromosome and bacterial artificial chromosome...

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Publication status:
Published

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Publisher copy:
10.1006/geno.2000.6128

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Journal:
Genomics
Volume:
64
Issue:
3
Pages:
221-229
Publication date:
2000-03-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:bdb1ced3-f0cc-4de5-8b3c-4970b3b0c726
Source identifiers:
37426
Local pid:
pubs:37426

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