- Abstract:
-
Chemerin is a potent macrophage chemoattractant protein. We used murine peritoneal exudate cells (PECs) in adhesion, flow cytometry, and confocal microscopy assays to test the hypothesis that chemerin can also contribute to inflammation by promoting macrophage adhesion. Chemerin stimulated the adhesion of PECs to the extracellular matrix protein fibronectin and to the adhesion molecule VCAM-1 within a minute, with an EC(50) of 322 and 196 pM, respectively. Experiments using pertussis toxin an...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.0902154
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 185
- Issue:
- 6
- Pages:
- 3728-3739
- Publication date:
- 2010-09-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:bdaccba8-17b6-4256-972c-1de0c40eccee
- Source identifiers:
-
67472
- Local pid:
- pubs:67472
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5.
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