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Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5.

Abstract:

Chemerin is a potent macrophage chemoattractant protein. We used murine peritoneal exudate cells (PECs) in adhesion, flow cytometry, and confocal microscopy assays to test the hypothesis that chemerin can also contribute to inflammation by promoting macrophage adhesion. Chemerin stimulated the adhesion of PECs to the extracellular matrix protein fibronectin and to the adhesion molecule VCAM-1 within a minute, with an EC(50) of 322 and 196 pM, respectively. Experiments using pertussis toxin an...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.0902154

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
185
Issue:
6
Pages:
3728-3739
Publication date:
2010-09-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:bdaccba8-17b6-4256-972c-1de0c40eccee
Source identifiers:
67472
Local pid:
pubs:67472

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