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Journal article

Lack of evidence for the efficacy of memantine in mild Alzheimer disease.

Abstract:

OBJECTIVE: We directly assessed the clinical trials' evidence for memantine's efficacy in mild Alzheimer disease (AD). Memantine is indicated in the United States and Europe for moderate to severe AD, which is diagnosed if a patient has a Mini-Mental State Examination (MMSE) score of less than 15 or less than 20, respectively. Yet memantine is very frequently prescribed for mild AD and mild cognitive impairment, and a manufacturer-sponsored meta-analysis claimed its efficacy in mild AD. DATA ...

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Publication status:
Published

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Publisher copy:
10.1001/archneurol.2011.69

Authors


Schneider, LS More by this author
Dagerman, KS More by this author
Higgins, JP More by this author
McShane, R More by this author
Journal:
Archives of neurology
Volume:
68
Issue:
8
Pages:
991-998
Publication date:
2011-08-05
DOI:
EISSN:
1538-3687
ISSN:
0003-9942
URN:
uuid:bda6b177-ff39-4734-8137-664ef3fd1a64
Source identifiers:
131204
Local pid:
pubs:131204

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