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Learning-induced plasticity in medial prefrontal cortex predicts preference malleability

Abstract:

Learning induces plasticity in neuronal networks. As neuronal populations contribute to multiple representations, we reasoned plasticity in one representation might influence others. We used human fMRI repetition suppression to show that plasticity induced by learning another individual's values impacts upon a value representation for oneself in medial prefrontal cortex (mPFC), a plasticity also evident behaviorally in a preference shift. We show this plasticity is driven by a striatal "predi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuron.2014.12.033

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Wellcome Trust More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neuron Journal website
Volume:
85
Issue:
2
Pages:
418-428
Publication date:
2015-01-21
Acceptance date:
2014-12-10
DOI:
ISSN:
0896-6273 and 1097-4199
Pmid:
25611512

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