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Proteomic-based identification of CD4-interacting proteins in human primary macrophages.

Abstract:

BACKGROUND: Human macrophages (Mφ) express low levels of CD4 glycoprotein, which is constitutively recycled, and 40-50% of its localization is intracellular at steady-state. Although CD4-interacting proteins in lymphoid cells are well characterised, little is known about the CD4 protein interaction-network in human Mφ, which notably lack LCK, a Src family protein tyrosine kinase believed to stabilise CD4 at the surface of T cells. As CD4 is the main cellular receptor used by HIV-1, knowledge ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
PloS one
Volume:
6
Issue:
4
Pages:
e18690
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:bda3f371-fcec-442c-8393-4684ab7008c8
Source identifiers:
135107
Local pid:
pubs:135107

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