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Synthetic approaches towards phorbols

Abstract:

The work described herein is concerned with the synthesis of phorbol natural products. The approach to these biological derivatives explored in this study utilised an intramolecular Diels- Alder reaction of a furan diene (IMDAF) precursor to establish the tigliane hydrocarbon skeleton and an intramolecular aldol cyclisation to construct the functionalised A-ring. Additionally, the subsequent elaboration of the phorboid cycloadducts could access highly functionalised ingenane analogues by ...

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Institution:
University of Oxford
Department:
Mathematical and Physical Sciences Division
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
1994
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603835510
URN:
uuid:bda30235-5847-4f0b-a033-cb07942885fe
Local pid:
td:603835510
Language:
English
Subjects:

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