Journal article
Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
- Abstract:
-
The IL23R region on chromosome 1 exhibits complex associations with ankylosing spondylitis (AS). We used publicly available epigenomic information and historical genetic association data to identify a potential regulatory element (PRE) in the intergenic region between IL23R and IL12RB2, which includes two single-nucleotide polymorphisms (SNPs) independently associated with AS —rs924080 (P=2×10− 3) and rs11578380 (P=2×10− 4). In luciferase reporter assays, this PRE showed silencer activity (Po...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ National Institute for Health Research
More from this funder
Funding agency for:
Knight, J
Grant:
20773
+ National Institute for
Health Research
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Funding agency for:
Vecellio, M
Grant:
A93081
+ Arthritis Research UK
More from this funder
Funding agency for:
Roberts, A
Knight, J
Grant:
20402
20773
20796
Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Genes and Immunity More from this journal
- Volume:
- 18
- Pages:
- 105-108
- Publication date:
- 2017-01-01
- Acceptance date:
- 2017-02-21
- EISSN:
-
1476-5470
- ISSN:
-
1466-4879
Item Description
- Pubs id:
-
pubs:687443
- UUID:
-
uuid:bda0afc1-49e3-4f8a-8642-b42c75267d43
- Local pid:
-
pubs:687443
- Deposit date:
-
2017-03-30
Terms of use
- Copyright holder:
- © 2016 Roberts, et al
- Copyright date:
- 2017
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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