Non-hydrolytic functions of acetylcholinesterase. The significance of C-terminal peptides.

Journal article

This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration. More specifically, C-terminal sequences of acetylcholinesterase may act as signalling molecules in key brain regions characteristically vulnerable to Alzheimer's, Parkinson's and motor neuron disease.

Authors: Greenfield, S; Zimmermann, M; Bond, C

• Publication status: Published
• Journal: FEBS journal
• Volume: 275
• Issue: 4
• Pages: 604-611
• Publication date: 2008-02-01
• DOI: 10.1111/j.1742-4658.2007.06235.x
• EISSN: 1742-4658
• ISSN: 1742-464X
• Language: English
• Keywords: Animals; Alzheimer Disease; Parkinson Disease; Models, Biological; Humans; Peptides; Signal Transduction; Acetylcholinesterase; Motor Neuron Disease; Nerve Degeneration