Journal article
On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation
- Abstract:
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Determining the mechanisms by which genes are switched on and off during development is a key aim of current biomedical research. Gene transcription has been widely observed to occur in a discontinuous fashion, with short bursts of activity interspersed with periods of inactivity. It is currently not known if or how this dynamic behaviour changes as mammalian cells differentiate. To investigate this, using an on-microscope analysis, we monitored mouse α-globin transcription in live cells thro...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.7MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-022-33977-4
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Funding
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 13
- Issue:
- 1
- Article number:
- 6641
- Place of publication:
- England
- Publication date:
- 2022-11-04
- Acceptance date:
- 2022-10-07
- DOI:
- EISSN:
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2041-1723
- Pmid:
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36333299
Item Description
- Language:
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English
- Keywords:
- Subjects:
- Pubs id:
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1300674
- Local pid:
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pubs:1300674
- Deposit date:
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2023-02-03
Terms of use
- Copyright holder:
- Jeziorska et al.
- Copyright date:
- 2022
- Rights statement:
- © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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