Journal article
Lipid degradation promotes prostate cancer cell survival.
- Abstract:
-
Prostate cancer is the most common male cancer and androgen receptor (AR) is the major driver of the disease. Here we show that Enoyl-CoA delta isomerase 2 (ECI2) is a novel AR-target that promotes prostate cancer cell survival. Increased ECI2 expression predicts mortality in prostate cancer patients (p = 0.0086). ECI2 encodes for an enzyme involved in lipid metabolism, and we use multiple metabolite profiling platforms and RNA-seq to show that inhibition of ECI2 expression leads to decreased...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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- Files:
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(pdf, 3.6MB)
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- Publisher copy:
- 10.18632/oncotarget.16123
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Authors
Funding
Norwegian Cancer Society
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Norwegian Research Council
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Southern and Eastern Norway Regional Health Authority
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University of Oslo
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Bibliographic Details
- Publisher:
- Impact Journals Publisher's website
- Journal:
- Oncotarget Journal website
- Volume:
- 8
- Issue:
- 24
- Pages:
- 38264-38275
- Publication date:
- 2017-03-05
- Acceptance date:
- 2017-03-01
- DOI:
- EISSN:
-
1949-2553
- ISSN:
-
1949-2553
- Pubs id:
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pubs:817469
- URN:
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uri:bd91bd87-f47a-41d5-8e80-2c032d6aff16
- UUID:
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uuid:bd91bd87-f47a-41d5-8e80-2c032d6aff16
- Local pid:
- pubs:817469
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Itkonen et al
- Copyright date:
- 2017
- Notes:
- Copyright: Harri M. Itkonen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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