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Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction

Abstract:

TNF is a primitive protein that has emerged from more than 550 million years of evolution. Our bioinformatics study of TNF from nine different taxa in vertebrates revealed several conserved regions in the TNF sequence. By screening overlapping peptides derived from human TNF to determine their role in three different TNF-induced processes--apoptosis, necrosis and NF-κB stimulation--we found that TNF conserved regions are mostly related to cell death rather than NF-κB stimulation. Among the mo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/jcs.175463

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Publisher:
Company of Biologists Publisher's website
Journal:
Journal of Cell Science Journal website
Volume:
129
Issue:
1
Pages:
108-120
Publication date:
2016-01-04
Acceptance date:
2015-11-10
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Pmid:
26729029
Source identifiers:
587699

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