Distinguishing direct from indirect roles for bicoid mRNA localization factors.

Journal article

Localization of bicoid mRNA to the anterior of the Drosophila oocyte is essential for patterning the anteroposterior body axis in the early embryo. bicoid mRNA localizes in a complex multistep process involving transacting factors, molecular motors and cytoskeletal components that remodel extensively during the lifetime of the mRNA. Genetic requirements for several localization factors, including Swallow and Staufen, are well established, but the precise roles of these factors and their relat...

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Authors: Weil, T; Xanthakis, D; Parton, R; Dobbie, I; Rabouille, C

• Publication status: Published
• Journal: Development (Cambridge, England)
• Volume: 137
• Issue: 1
• Pages: 169-176
• Publication date: 2010-01-01
• DOI: 10.1242/dev.044867
• EISSN: 1477-9129
• ISSN: 0950-1991
• Language: English
• Keywords: Oogenesis; Dyneins; Embryo, Nonmammalian; Microscopy, Immunoelectron; Microscopy, Fluorescence; Gene Expression Regulation, Developmental; Drosophila Proteins; Cell Membrane; Homeodomain Proteins; Trans-Activators; Oocytes; RNA, Messenger; Drosophila; Animals; Actins; In Situ Hybridization; RNA-Binding Proteins