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Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure.

Abstract:

BACKGROUND: Chronic heart failure (CHF) is associated with abnormalities of skeletal muscle metabolism. This may be due to impaired oxygen delivery as a result of endothelial dysfunction. AIMS: We postulated that ascorbic acid would improve oxygen delivery to exercising muscle and improve skeletal muscle metabolism. METHODS: We studied skeletal muscle metabolism using (31)P magnetic resonance spectroscopy in 39 CHF patients. Endothelial function was assessed by changes in pulse wave velocity....

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Publication status:
Published

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Journal:
European journal of heart failure
Volume:
9
Issue:
3
Pages:
287-291
Publication date:
2007-03-05
DOI:
EISSN:
1879-0844
ISSN:
1388-9842
URN:
uuid:bd7eee62-3768-4fc7-863c-49ae5b8f9dc5
Source identifiers:
106814
Local pid:
pubs:106814

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