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Journal article

Human snRNA genes use polyadenylation factors to promote efficient transcription termination.

Abstract:

RNA polymerase II transcribes both protein coding and non-coding RNA genes and, in yeast, different mechanisms terminate transcription of the two gene types. Transcription termination of mRNA genes is intricately coupled to cleavage and polyadenylation, whereas transcription of small nucleolar (sno)/small nuclear (sn)RNA genes is terminated by the RNA-binding proteins Nrd1, Nab3 and Sen1. The existence of an Nrd1-like pathway in humans has not yet been demonstrated. Using the U1 and U2 genes ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkt892

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Funding agency for:
Murphy, S
Grant:
WT092483
More from this funder
Funding agency for:
O'Reilly, D
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
42
Issue:
1
Pages:
264-275
Publication date:
2014-01-01
Acceptance date:
2013-09-11
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Source identifiers:
432585
Language:
English
Keywords:
Pubs id:
pubs:432585
UUID:
uuid:bd723c7d-5d2a-4b6c-bdaa-b0c3b5382ccd
Local pid:
pubs:432585
Deposit date:
2013-11-16

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