- Abstract:
-
IL-17 is implicated in the pathogenesis of rheumatoid arthritis (RA) and has previously been shown to be induced by tumor necrosis factor (TNF) in vitro. The aim of this study was to assess the impact of TNF inhibition on IL-17 production in collagen-induced arthritis, a model of RA. TNF blockade using TNFR-Fc fusion protein or anti-TNF monoclonal antibody reduced arthritis severity but, unexpectedly, expanded populations of Th1 and Th17 cells, which were shown by adoptive transfer to be path...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.20072707
-
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- Publisher:
- Rockefeller University Press
- Journal:
- The Journal of experimental medicine
- Volume:
- 205
- Issue:
- 11
- Pages:
- 2491-2497
- Publication date:
- 2008-10-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:bd6ee5b5-afe1-433a-8731-7266c5dbd7d1
- Source identifiers:
-
227177
- Local pid:
- pubs:227177
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.
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