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Journal article

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.

Abstract:

IL-17 is implicated in the pathogenesis of rheumatoid arthritis (RA) and has previously been shown to be induced by tumor necrosis factor (TNF) in vitro. The aim of this study was to assess the impact of TNF inhibition on IL-17 production in collagen-induced arthritis, a model of RA. TNF blockade using TNFR-Fc fusion protein or anti-TNF monoclonal antibody reduced arthritis severity but, unexpectedly, expanded populations of Th1 and Th17 cells, which were shown by adoptive transfer to be path...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20072707

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Publisher:
Rockefeller University Press
Journal:
The Journal of experimental medicine
Volume:
205
Issue:
11
Pages:
2491-2497
Publication date:
2008-10-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:bd6ee5b5-afe1-433a-8731-7266c5dbd7d1
Source identifiers:
227177
Local pid:
pubs:227177

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