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Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey.

Abstract:

We have studied the effects of stimulating the pedunculopontine nuclei through a fully implanted macroelectrode with a s.c. implantable pulse generator whose parameters can be programmed telemetrically, in a macaque before and after inducing Parkinsonian akinesia with MPTP. Our results show that in the normal monkey high frequency stimulation of the pedunculopontine nuclei reduces motor activity while low frequency stimulation increases it significantly over baseline. After making the monkey ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Neuroreport
Volume:
15
Issue:
17
Pages:
2621-2624
Publication date:
2004-12-01
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
Source identifiers:
147663
Language:
English
Keywords:
Pubs id:
pubs:147663
UUID:
uuid:bd601c4c-ef10-427f-b7b9-45b376c63751
Local pid:
pubs:147663
Deposit date:
2012-12-19

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