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Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey.

Abstract:

We have studied the effects of stimulating the pedunculopontine nuclei through a fully implanted macroelectrode with a s.c. implantable pulse generator whose parameters can be programmed telemetrically, in a macaque before and after inducing Parkinsonian akinesia with MPTP. Our results show that in the normal monkey high frequency stimulation of the pedunculopontine nuclei reduces motor activity while low frequency stimulation increases it significantly over baseline. After making the monkey ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Neuroreport
Volume:
15
Issue:
17
Pages:
2621-2624
Publication date:
2004-12-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:bd601c4c-ef10-427f-b7b9-45b376c63751
Source identifiers:
147663
Local pid:
pubs:147663

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