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Heterogeneity of carbonyl reduction in subcellular fractions and different organs in rodents

Abstract:

The pattern and distribution of carbonyl reduction in liver, kidney and adrenal gland subcellular fractions of NMRI mice, Wistar rats and Hartley guinea pigs were examined using the ketone compound metyrapone (2-methyl-1,2-di(3-pyridyl)1-propanone) commonly used as a diagnostic cytochrome P450 inhibitor. A direct HPLC method for alcohol metabolite determination instead of the indirect spectrophotometric recording of pyridine nucleotide oxidation at 340 nm was applied. All the tissues examined...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Mangoura, SA More by this author
Netter, KJ More by this author
Journal:
Biochemical Pharmacology
Volume:
42
Issue:
SUPPL. 1
Publication date:
1991-12-11
DOI:
ISSN:
0006-2952
URN:
uuid:bd4d7935-ead8-4450-b5e1-6afc34cc4dc2
Source identifiers:
109529
Local pid:
pubs:109529
Language:
English

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