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Induction and maintenance of CX3CR1-intermediate peripheral memory CD8+ T cells by persistent viruses and vaccines

Abstract:

The induction and maintenance of T cell memory is critical to the success of vaccines. A recently described subset of memory CD8+ T cells defined by intermediate expression of the chemokine receptor CX3CR1 was shown to have self-renewal, proliferative, and tissue-surveillance properties relevant to vaccine-induced memory. We tracked these cells when memory is sustained at high levels: memory inflation induced by cytomegalovirus (CMV) and adenovirus-vectored vaccines. In mice, both CMV and vac...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.03.074

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
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Funding agency for:
Klenerman, P
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
23
Issue:
3
Pages:
768–782
Publication date:
2018-04-17
Acceptance date:
2018-03-16
DOI:
ISSN:
2211-1247
Pubs id:
pubs:835388
URN:
uri:bd412cf9-9f9d-4968-ae85-761a1f9068bd
UUID:
uuid:bd412cf9-9f9d-4968-ae85-761a1f9068bd
Local pid:
pubs:835388

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