- Abstract:
-
PURPOSE: To evaluate the adequacy of a Poisson tumor control probability (tcp) model and the impact of hypoxia on tumor cure. METHODS AND MATERIALS: A human colon adenocarcinoma cell line, WiDr, was grown as multicellular spheroids of different diameters. Measurements were made of cell survival and spheroid cure following 300-kV X-ray external beam irradiation in air and nitrogen. Cell survival data were fitted using a two-compartment and an oxygen diffusion model. Spheroid cure data were fit...
Expand abstract - Publisher copy:
- 10.1016/s0360-3016(00)01533-9
-
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- Journal:
- International journal of radiation oncology, biology, physics
- Volume:
- 49
- Issue:
- 4
- Pages:
- 1109-1118
- Publication date:
- 2001-03-05
- DOI:
- EISSN:
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1879-355X
- ISSN:
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0360-3016
- URN:
-
uuid:bd3e83eb-0aba-4637-a41e-8854c21d6807
- Source identifiers:
-
276349
- Local pid:
- pubs:276349
- Copyright date:
- 2001
Journal article
Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: the significance of hypoxia on tumor control modelling.
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