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Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: the significance of hypoxia on tumor control modelling.

Abstract:

PURPOSE: To evaluate the adequacy of a Poisson tumor control probability (tcp) model and the impact of hypoxia on tumor cure. METHODS AND MATERIALS: A human colon adenocarcinoma cell line, WiDr, was grown as multicellular spheroids of different diameters. Measurements were made of cell survival and spheroid cure following 300-kV X-ray external beam irradiation in air and nitrogen. Cell survival data were fitted using a two-compartment and an oxygen diffusion model. Spheroid cure data were fit...

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Journal:
International journal of radiation oncology, biology, physics
Volume:
49
Issue:
4
Pages:
1109-1118
Publication date:
2001-03-05
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
URN:
uuid:bd3e83eb-0aba-4637-a41e-8854c21d6807
Source identifiers:
276349
Local pid:
pubs:276349

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