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Limbic over-activity in depression during preserved performance on the n-back task.

Abstract:

The profile of cognitive dysfunction observed in patients with major depressive disorder (MDD) may be partially attributed to a deficit in the central executive component of working memory (WM). This could be the consequence of a functional deficit in regions of cortex that are associated with WM function in healthy adults. In order to investigate this assertion, ten patients with a diagnosis of MDD and ten matched healthy controls undertook a parametric WM task (i.e. the n-back task) during ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
NeuroImage
Volume:
29
Issue:
1
Pages:
203-215
Publication date:
2006-01-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:bd3e1ad4-bb6c-4a98-9685-5cefb1e2e660
Source identifiers:
139198
Local pid:
pubs:139198

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