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The SIRP family of receptors and immune regulation

Abstract:

The immune system must be highly regulated to obtain optimal immune responses for the elimination of pathogens without causing undue side effects. This tight regulation involves complex interactions between membrane proteins on leukocytes. Members of the signal-regulatory protein (SIRP) family, which are expressed mainly by myeloid cells, provide one example of these regulatory membrane proteins. There are three SIRP-family genes that encode proteins that have similar extracellular regions bu...

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Publisher copy:
10.1038/nri1859

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Journal:
Nature Reviews Immunology
Volume:
6
Issue:
6
Pages:
457-464
Publication date:
2006-06-05
DOI:
ISSN:
1474-1733
URN:
uuid:bd33dbbf-8603-4b87-a00d-e0f1f7a485a4
Source identifiers:
171842
Local pid:
pubs:171842
Language:
English

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