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The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles.

Abstract:

Detailed characterization of the protective T-cell response in salmonellosis is a pressing unmet need in light of the global burden of human Salmonella infections and the likely contribution of CD4 T cells to immunity against this intracellular infection. In previous studies screening patient sera against antigen arrays, SseB was noteworthy as a serodominant target of adaptive immunity, inducing significantly raised antibody responses in HIV-seronegative compared with seropositive patients. S...

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Publication status:
Published

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Publisher copy:
10.1111/imm.12327

Authors


Reynolds, CJ More by this author
Blohmke, CJ More by this author
Darton, TC More by this author
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Publisher:
Blackwell Publishing Ltd
Journal:
Immunology
Volume:
143
Issue:
3
Pages:
438-446
Publication date:
2014-11-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:bd2efbad-fbb4-41e1-97e6-3693633cc96a
Source identifiers:
469451
Local pid:
pubs:469451

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