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Three genes expressing Kunitz domains in the epididymis are related to genes of WFDC-type protease inhibitors and semen coagulum proteins in spite of lacking similarity between their protein products.

Abstract:

BACKGROUND: We have previously identified a locus on human chromosome 20q13.1, encompassing related genes of postulated WFDC-type protease inhibitors and semen coagulum proteins. Three of the genes with WFDC motif also coded for the Kunitz-type protease inhibitor motif. In this report, we have reinvestigated the locus for homologous genes encoding Kunitz motif only. The identified genes have been analyzed with respect to structure, expression and function. RESULTS: We identified three novel ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2091-12-55

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Alfred Österlunds Stiftelse More from this funder
MAS Cancer Foundation More from this funder
Fundación Federico SA More from this funder
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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC biochemistry Journal website
Volume:
12
Issue:
1
Pages:
55
Publication date:
2011-01-01
DOI:
EISSN:
1471-2091
ISSN:
1471-2091
URN:
uuid:bd29e92d-e49f-4e4d-9a54-257d66c76ce8
Source identifiers:
365867
Local pid:
pubs:365867

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