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Journal article

The effect of iron availability on transcription of the Neisseria meningitidis fHbp gene varies among clonal complexes.

Abstract:

Factor H binding protein (fHbp) is a major antigenic component of novel vaccines designed to protect against meningococcal disease. Prediction of the potential coverage of these vaccines is difficult, as fHbp is antigenically variable and levels of expression differ among isolates. Transcriptional regulation of the fHbp gene is poorly understood, although evidence suggests that oxygen availability is involved. In this study iron accessibility was found to affect fHbp transcription. However, r...

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Publication status:
Published

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Publisher copy:
10.1099/mic.0.054957-0

Authors


Journal:
Microbiology (Reading, England)
Volume:
158
Issue:
Pt 4
Pages:
869-876
Publication date:
2012-04-05
DOI:
EISSN:
1465-2080
ISSN:
1350-0872
URN:
uuid:bd26cbcb-5c66-4d88-a6d0-e2f9f1a04439
Source identifiers:
257094
Local pid:
pubs:257094

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